Rink Amide Resin (100–200 Mesh): Solid Support for C-Terminal Amide Peptides
Rink Amide Resin is a solid-phase synthesis resin used primarily for producing C-terminally amidated peptides via Fmoc-based SPPS (Solid-Phase Peptide Synthesis). It consists of a polystyrene-divinylbenzene (PS-DVB) matrix functionalized with the Rink amide linker, which releases peptides with a –CONH₂ (amide) group at the C-terminus upon cleavage with trifluoroacetic acid (TFA).
With a particle size of 100–200 mesh (approximately 75–150 µm), this resin offers a good balance between surface area and flow properties, making it compatible with both manual and automated synthesizers.
Product Specifications
Matrix: Polystyrene cross-linked with ~1% divinylbenzene (DVB)
Linker: Rink amide (acid-labile)
Functional Group: Amide precursor
Loading: Typically 0.4–0.8 mmol/g (varies by supplier and grade)
Particle Size: 100–200 mesh (approx. 75–150 µm)
Swelling: Good in DMF, DCM, NMP, etc.
Protecting Group Compatibility: Fmoc (base-labile)
Key Features
C-Terminal Amide Peptides: Enables direct synthesis of peptides with an amide at the C-terminus, mimicking natural peptide structures.
Fmoc Chemistry Compatible: Widely used in Fmoc/tBu SPPS protocols.
Versatile: Ideal for therapeutic peptides, enzyme substrates, or bioactive peptide analogs.
100–200 Mesh Size: Offers optimized surface area for high reactivity and efficient washing.
Applications
Peptide therapeutics with amide termini for improved bioactivity or stability
Combinatorial chemistry and peptide library synthesis
Biological mimicry for naturally amidated peptide hormones and neurotransmitters
Structure-activity relationship (SAR) studies
Cleavage & Deprotection
Use 95% TFA with scavengers (e.g., water, triisopropylsilane, EDT) for 1–3 hours.
Results in a fully deprotected peptide with a C-terminal –CONH₂ group.
Handling & Storage
Store dry, sealed, and away from light and moisture.
Swell in DMF or DCM before synthesis.
Handle with care to avoid exposure to strong acids outside of cleavage conditions.
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